Effect of Extrapyramidal Signs and Lewy Bodies on Survival in Patients With Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Effect of extrapyramidal signs and Lewy bodies on survival in patients with Alzheimer disease.
BACKGROUND Patients with Alzheimer disease (AD) who have psychiatric and parkinsonian symptoms experience faster cognitive deterioration and shorter survival vs those without such disease features. Extrapyramidal signs (EPSs) in particular have been associated with the presence of Lewy bodies (LBs) on autopsy and with poorer survival in patients with AD. Lewy bodies found at autopsy are not alw...
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OBJECTIVE To identify personality traits that distinguish dementia with Lewy bodies (DLB) from Alzheimer disease (AD). METHODS We examined 290 participants enrolled in a longitudinal study (nondemented control = 34, DLB = 128, AD = 128) followed to autopsy. As part of the annual interview with the collateral source, the clinician asked about specific changes in personality, interests, and dri...
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Dementia with Lewy (DLB) bodies is the most common type of degenerative dementia after Alzheimer Disease (AD). Although an accurate diagnosis of DLB is important for adequate prognosis and therapy, its differentiation from other dementias and, especially, from AD may be extremely challenging for clinicians, as highlighted by the high variability in reported sensitivity (0.22 – 0.83) and specifi...
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Dementia with Lewy bodies ('Lewy body dementia' or 'diffuse Lewy body disease') (DLB) is the second most common form of dementia to affect elderly people, after Alzheimer's disease. A combination of the clinical symptoms of Alzheimer's disease and Parkinson's disease is present in DLB and the disorder is classified as a 'parkinsonian syndrome', a group of diseases which also includes Parkinson'...
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INTRODUCTION Autonomic dysfunction is a well-known feature in neurodegenerative dementias, especially common in α-synucleinopathies like dementia with Lewy bodies and Parkinson's disease with dementia. The most common symptoms are orthostatic hypotension, incontinence and constipation, but its relevance in clinical practice is poorly understood. There are no earlier studies addressing the influ...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2002
ISSN: 0003-9942
DOI: 10.1001/archneur.59.4.588